Bacterial Endotoxin: Effects on Erythropoiesis
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چکیده
منابع مشابه
Effects of Bacterial Endotoxin on Rabbit Platelets
Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet fa...
متن کاملEffects of bacterial endotoxin on drug pharmacokinetics.
Bacterial endotoxin (lipopolysaccharide) has a variety of biological and immunological activities. Endotoxin-induced physiological changes in several organs might modify the pharmacokinetic behavior, including the biliary and urinary excretions and hepatic metabolism, of various drugs. We have conducted a series of studies as part of a program for the development of guidelines for the safe use ...
متن کاملThe Effects of Bacterial Endotoxin on Lipide Metabolism
Single intravenous injections of Shear's polysaccharide in varying dosages invariably produced an elevation in the levels of the total serum lipides 24 hours after injection of endotoxin. The total serum cholesterol and lipide phosphorus were also affected, although they did not change with smaller doses of endotoxin and were rarely elevated to the same degree as were the total serum lipides. T...
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13 Feder, L. S. and Laskin, D. L. (1994) J. Leukocyte Biol. 55, 507-513 14 Blouin, A., Bolender, R. P. and Weibel, E. R. (1977) J. Cell Biol. 72, 441-455 15 Nagura, H., Koshikawa, T., Fukuda, Y. and Asai, J. (1986) Virchow’s Arch. Pathol. [A] 409, 407-416 16 McCloskey, T. W., Todaro, J. A. and Laskin, D. L. (1992) Hepatology 16, 191-203 17 Spitzer, J. A., Zhang, P. and Mayer, A. M. S. (1994) J....
متن کاملContamination of erythropoietin by endotoxin: in vivo and in vitro effects on murine erythropoiesis.
Endotoxin was detected in all erythropoietin preparations tested and was removed from four lots, without loss of erythropoietic activity, by adsorption with limulus amebocyte lysate. Comparison of adsorbed (endotoxin-depleted) and nonadsorbed (endotoxin-containing) erythropoietin preparations demonstrated significant inhibition of CFU-e and BFU-e in vitro by nonadsorbed erythropoietin at concen...
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ژورنال
عنوان ژورنال: Blood
سال: 1966
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v27.3.363.363